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The assay was performed on a GenomeLab GeXP genetic analysis system (AB SCIEX, USA) using capillary electrophoresis, with results interpreted by the system's built-in software in accordance with standard operating procedures

The mechanism suggested by Stenuit et al

FIGURE 3 3.4 Evaluation of enzymatic antioxidants and possible sources of ROS in monocytes In the next step, we assessed other essential components of the antioxidant defense system: catalase (CAT), superoxide dismutases (SODs), peroxiredoxin 1 (PRDX1), and heme oxygenase 1 (HMOX1) (Figure 4A)

Melatonin has an easier access to subcellular organelles such as the mitochondria, the primary sites for ROS production due to their lipophilic and hydrophilic characteristics (Reiter et al., 2003