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10.3390/biom8010003 39 GlaserT.BaiocchiL.ZhouT.FrancisH.LenciI.GrassiG.et al (2020)

For someone deficient in vitamin B12, your provider may recommend a larger starting dose to increase your value quickly before leveling out on a maintenance dose

Acetylation or succinylation of lysine residue located at position 122 (Lys122) within the electrostatic loop reduces its net charge from + 1 to 0 or 1, respectively, hindering the electrostatic guiding of anionic O 2 towards the active site