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Lastly, several lines of experimental evidence from animal studies are also provided in this study which jointly offers strong support for the involvement of PDI in mediating APAP-induced liver injury in vivo: i

In an adult patient (hypothyroid with thyroid hormone supplementation) who received an oral tracer dose of 123 I radioiodine, approximately 0.01% of the dose was recovered in tears collected over a 4-hour period