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The SECIS association factors regulate the expression of selenoprotein by displacement of SECIS-binding protein 2 (SBP2), which specifically binds SECIS to dry EF elongation factor with specificity for selenocysteyl-tRNA (Sec-tRNA [Ser] Sec )

In addition to the leak and pore pathways, there is also the unrestricted (or apoptotic) pathway, where severe damage to the gut mucosa results in death of epithelial cells and permits unrestricted paracellular transport of large molecules and bacteria

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