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CYPs AND DRUG-DRUG INTERACTIONS

For example, cimetidine acts as an OCT2 inhibitor that inhibits the transportation of cisplatin in the kidney to protect against AKI [64], carvedilol works as an antioxidant against the oxidative stress process [65], cilastatin inhibits the apoptotic pathway [66], and rosiglitazone reduces inflammation [67]

doi: 10.1016/j.biomaterials.2022.121827 171 RussoAMaiolinoSPagliaraVUngaroFTatangeloFLeoneAet al

Although cortical volumetric bone mineral density (BMD) and mineral concentration remained unchanged, the findings suggest that GHS treatments can lead to an increase in bone size without necessarily impacting bone density