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Homozygous MRPS7 protein Mitochondrial location: Matrix Mitochondrial Ribosome protein: Small subunit Clinical Onset Congenital Sensorineural deafness Sensorineural deafness Systemic Vomiting Hepatic failure: Hepatomegaly Renal failure Course: More severe sib died in 2nd decade Laboratory Oxidative enzyme deficiencies Liver: Complex I, III & IV Muscle: Borderline changes Serum lactate: High Hypoglycemia Urinary organic acids: 3-hydroxybutyrate peak Muscle Lipid: Increased SDH & COX: Normal Liver: Steatosis

The exact window also depends on the sequence, since shorter peptides and those with oxidation-prone residues degrade faster than stable ones

Clin Pharmacokinet (2020) 59(7):84956