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This protection is likely due to increased growth of new neurons in the hippocampus, improved signaling of brain-derived neurotrophic factor (BDNF), better synaptic function, and reduced brain inflammation (Nichol et al., 2008)

By adopting these new and updated standards, implementation specifications, certification criteria, and conditions of certification, provisions in the HTI-1 final rule advance interoperability, improve transparency, and support the access, exchange, and use of electronic health information

Genetic variants associated with uric acid levels mainly include purine metabolism (e.g., XDH, HPRT1), urate transporters (e.g., SLC2A9, SLC22A12), and renal urate processing regulators (e.g., ABCG2)

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