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Abelln Lpez, Olga lvarez Montes, Mercedes Canellas Manrique, M Jos San Telesforo Navarro, M Mercedes Parrilla Laso, M ngeles Aragoneses Caas, Angela Aun Muelas HC Los Ybenes, Esther Valds Cruz, Consuelo Mayoral Lopez, Teresa Gijon Seco, Francisca Martinez Vallejo

Further mechanistic studies showed that NNMTi increases intracellular NAD levels and activates the SIRT1 pathway by inhibiting NNMT, thereby suppressing the transcription of adipogenic genes and preventing the maturation of preadipocytes.This research provides a new perspective for understanding the molecular mechanism of adipocyte differentiation, confirms the key role of NNMTi in regulating adipogenesis, and lays a foundation for subsequent obesity intervention studies

Monitoring For patients with symptomatic B12 deficiency (e.g

Targeted support