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This network underscores the essential role of bidirectional microbiotametaboliteimmune crosstalk in SLE and provides a rationale for targeted interventions (such as FMT, probiotics, metabolite supplementation, etc.), aiming to restore immune homeostasis through multiple pathways (Fig

NRF2 signaling pathway The transcription factor NRF2 is a master regulator of the antioxidant response and a key target for inhibiting ferroptosis in individuals with DACI

Additionally, these electrodes are linked to a pulse generator implanted in the thoracic cavity

Oxidative DNA adducts such as 8-oxoG are not only lesions but also contextual signals that recruit base-excision machinery (e.g., OGG1) and remodel local chromatin, thereby coupling genome surveillance to transcriptional tuning