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Listed mechanisms include IR serine phosphorylation states, IRS-1 modifications, PI3K/AKT pathway attenuation, GLUT4 expression changes, SNARE complex assembly defects, Rab GTPase cycling alterations, AS160/Tbc1D4 dysregulation, mTORC1/mTORC2 signaling perturbations, and inflammatory mediator effects (TNF-, SOCS3, IL-6)

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Rights and permissions Copyright information 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG About this chapter Cite this chapter Hegedsov, A