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When present in the nucleus, these aggregates sequester transcription factors resulting in gene expression alterations (Labbadia and Morimoto, 2013), while when present in the cytosol, they may bind to diverse proteins resulting in an altered autophagy-lysosome pathway, reduced protein translation, synaptic dysfunction, reduced axonal transport, mitochondrial toxicity, and energy imbalance among others (Labbadia and Morimoto, 2013

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In addition to the abovementioned immunoglobulins and lactotransferrin, we have also identified glycosylated sites in host defense proteins such as haptoglobin and clusterin

121,122 However, some studies have demonstrated that glutamine supplementation protects against AKI and attenuates tubular apoptosis