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Moreover, low levels of riboflavin can cause a variety of health problems including growth retardation, sore throat, cheilosis, anaemia, renal damage, neurodegeneration, gastrointestinal tract disorders, stomatitis of the mouth and tongue and skin disorders (Reference Powers10)

A patient with favorable genetic predisposition to growth hormone anabolism (based on growth hormone receptor polymorphisms and IGF-1 signaling variants) may be a better candidate for dual therapy than someone with polymorphisms associated with protein catabolism

Adverse reactions to sulphonamide and sulphonamide-trimethoprim antimicrobials: clinical syndromes and pathogenesis