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High glucose could promote the production of TGF-1 and extracellular matrix (ECM) components such as fibronectin and collagen I, III, IV in renal tubular cells, thereby promoting tubulointerstitial fibrosis (22)

Cyanocobalamin, also known as vitamin B12, is used to treat and prevent vitamin B12 deficiency

Siezen and van Hylckama Vlieg, 2011)

267 Claudin-7 (Cldn-7), a member of the tight junction protein family, is closely related to inflammation and tumor development, and Cldn-7 deficiency can significantly upregulate the expression of -catenin and its downstream target genes c-myc and cyclin D1 by promoting aberrant activation of the Wnt/-catenin pathway, which in turn leads to abnormal cell proliferation and tumorigenesis