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Although ROS play essential roles in the maintenance of basal cellular activities such as chondrocyte proliferation and matrix remodeling in cartilage, excessive oxidative stress causes detrimental events such as cellular senescence 36,121 , dedifferentiation 122 , and apoptosis 123

The hippocampus and amygdala were selected a priori as representative limbic regions involved in affective and cognitive dimensions of pain, and the present supraspinal analysis was therefore designed to target sensoryaffective pain domains rather than to comprehensively survey all canonical pain modulatory regions

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