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Direct evidence for this mechanism comes from a study by Hu et al

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-Tocopherol has a protective effect on RBC membranes against lipid peroxidation [11, 19]

First, KEAP1 has been shown to have complex interactions with various other proteins besides NRF2 (Hushpulian et al., 2021) and concerns about potential side effects arise from the diverse array of cellular processes covered by KEAP1 interactor proteins, involving DNA replication, cytoskeletal dynamics, transcription, and apoptosis