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In this case, both the inhibition of MAT2A and methionine restriction reduce histone methylation modulating apoptosis, DNA repair and tumor necrosis factor (TNF) pathway promoting cisplatin sensibilization [177]

Methods: Here we employed genetic algorithms to subclassify a cohort of 849 patients previously classified into metabotypes of impaired VLDL secretion (A, n=541) or increased VLDL secretion (C, n=308) 1

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Then, the sections are transferred into graded ethanol (70%, 80%, 95%, 100%) for gradual dehydration, followed by xylene to make the sections transparent