(4)KO group: TPH1 knockout mice were treated i.p with APAP (TPH1, the rate-limiting enzyme for the synthesis of peripheral serotonin)
When you leave after treatment, you will feel better and look better
1.5 the time is treated in the more Changzhi of doubly, 2 times, 3 times, 4 times, 5 times or 10 times) or the using of more frequent CoQ10 (for example, frequency increases to 1.5 times, 2 times, 3 times, 4 times, 5 times, 10 times, 20 times or 24 times).In a plurality of embodiments, the selected more high dose that is used to treat the coenzyme Q10 of invasive tumor obstacle comprises about 0.001 to about 10.0, about 0.005 to about 10.0, about 0.01 to about 10.0, about 0.05 to about 5.0, about 0.05 to about 2.0, about 0.05 to about 1.0, about 0.05 to about 0.7, about 0.10 to about 0.50 or the skin of about 0.12 to 0.5mg CoQ10/ square centimeter.In other embodiments, the dosage with the skin of about 0.001,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.10,0.11,0.12,0.13,0.14,0.15,0.16,0.17,0.18,0.19,0.20,0.21,0.22,0.23,0.24,0.25,0.26,0.27,0.28,0.29,0.30,0.31,0.32,0.33,0.34,0.35,0.36,0.37,0.38,0.39,0.40,0.41,0.42,0.43,0.44,0.45,0.46,0.47,0.48,0.49,0.5mg, 0.6mg, 0.7mg., 0.8mg, 0.9mg or 1.0mg CoQ10/ square centimeter is applied to target tissue with coenzyme Q10.Should be appreciated that any scope as the upper limit or lower limit with these values is also intended to be part of the present invention, for example, about 0.15 skin to about 0.5mg CoQ10/ square centimeter
Oncotarget 8 , 3765737672 (2017)
