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In addition, although our mechanistic gain- and loss-of-function studies were supported by extensive in vivo validation, part of the functional characterization was performed using HL60-derived neutrophil cells

c-Abl inhibitors c-Abl, a critical non-receptor tyrosine kinase, functions as a key sensor of cellular stress and is widely expressed throughout the brain, playing an indispensable role in neuronal development and survival

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, a syndrome associated to increased intestinal permeability) which may then favour the transmission of noxious agents, such as bacteria or bacterial products, to the genito-urinary tract (18)