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The PF experiences peak tension at its calcaneal insertion during toe-off 31 , while mid-substance regions endure lower strain, potentially explaining site-specific histological adaptations (e.g., localized thickening) and mechanical disparities

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While ROS can function as second messengers regulating cellular reproduction, growth, differentiation, and signaling when maintained at optimal concentrations and dynamic equilibrium, exceeding critical ROS thresholds induces oxidative stress, leading to DNA damage, protein denaturation, and lipid peroxidationkey factors in CHD development