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Furthermore, these comprehensive effects up-regulate the HMOX1 to promote the Fe 2+ and lipid peroxides accumulation, thereby inducing immunogenic ferroptosis

Such rhythms reflect the existence of an intrinsic circadian clock that temporally orchestrates physiological processes to adapt the internal environment with the external cues

However, these multifunctional cells are increasingly recognized for their involvement in chronic inflammation, neuroimmune regulation, and autoimmune pathology