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Well look at the differences between these methods

doi:10.1016/j.ejmg.2019.103713

Retrieved May 3, 2025, from [ \- Link Opens in New Tab]( (Cautions that people with low blood pressure or a history of gout should not take niacin/niacinamide due to risk of hypotension and hyperuricemia

Although our experience suggests that hydroxocobalamin does not cause clinically significant interference with non-invasive pulse oximetry, there is evidence to suggest that co-oximetric blood gas analysis with several unique analyzers may be altered in the presence of hydroxocobalamin, specifically with false elevations of carboxyhemoglobin and methemoglobin concentrations and underestimation of true oxygen saturation values.5 There is no available evidence regarding the accuracy of other commonly utilized oximetric monitoring modalities (e.g., cerebral oximetry) following hydroxocobalamin administration