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By introducing known triggers of ECD into these 3D models, it would be possible to observe not only how ECs are directly affected, but also how their interactions with surrounding cell types are altered within the complex microenvironment of the spheroids

Among them, specifically targeting the downstream mediators of c-Met involved in tumor progression is a promising method, including the Grb2 SH2 domain, Src, MAPK, STAT3, Shp2 (Liu et al., 2018), and Fak (Jo et al., 2015)

Epitalon (sometimes spelled Epithalon) is another synthetic tetrapeptide and often described as Ala-Glu-Asp-Gly (AEDG)

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