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Indeed, hydrochlorothiazide gained widespread popularity following a controlled trial for the management of hypertension published in 1970 (Collins et al., 1990

Pancreas 2018;47:85663

It has been reported that ATRA or RAR enhances the uptake of THs through transcriptional upregulation of monocarboxylate transporter in the extraembryonic endoderm development period ( In conclusion, an increasing number of evidence demonstrates the regulation of thyroid hormones by vitamin A and its derivatives from the gene expression level to their effect on target tissues

(Reference Shin, Lee and Seo42,Reference Soeizi, Rafraf, Asghari-Jafarabadi, Ghaffari, Rezamand and Doostan45,Reference Fukino, Ikeda, Maruyama, Aoki, Okubo and Iso65,Reference De Maat, Pijl, Kluft and Princen67,Reference van het Hof, de Boer, Wiseman, Lien, Westrate and Tijburg68) Two assessors conducted the assessment independently