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Acknowledgements We apologize to the researchers who were not referenced owing to space limitations

While glutathione does not directly lower glucose, studies suggest supplementation may improve insulin sensitivity

Collectively, these antioxidants alleviate renal anemia by reducing premature erythrocyte death, prolonging erythrocyte lifespan in circulation, and addressing the oxidative stress imbalance inherent to CKD, making them promising adjuvant therapeutic agents alongside conventional EPO or iron supplementation

This review is particularly timely given recent global phosphoproteomic analyses providing new insights into dysregulation of the insulin signalling pathway