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The controversial reports about the expression of the IGF family and its connection to prostate cancer risk and development may be the result of the high degree of heterogeneity among prostate tumors, sampling bias, evaluation techniques, or the experimental design (105)

Natural derivatives have been increasingly appreciated for their potency in prevention and management of neurodegenerative diseases 35,49,50

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Annu Rev Food Sci Technol 10:597617 Santos-Parker JR, Strahler TR, Bassett CJ, Bispham NZ, Chonchol MB, Seals DR (2017) Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress