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However, only GPX4 scavenges membrane lipid hydroperoxides

This hyperglycemia develops progressively, with initial insulin resistance followed by a decrease in insulin secretion, resulting in sustained high blood glucose levels (32)

( A D ) 4T1 cells transfected with non-targeting small interfering RNA (siCTR) or 2 different combination pools of 4 individual siRNA for FADS1 (siFADS1_pool1 and pool2) and FADS2 (siFADS2_pool1 and pool2) and assessed by qRT-PCR ( A ) were treated ON with 0.1 M RSL3 ( B ) or 2 h with 1 M RSL3 ( C , D ) and assayed for cell survival ( B ), confocal analysis ( C ), and cytofluorimetric analysis ( D ) to measure lipid peroxidation

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