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Since the majority of research uses observational and correlational data, it is challenging to determine whether gut dysbiosis is a direct cause of CVD development or merely an effect of the illness state

10.1016/j.neuropharm.2012.02.015 Neuropharmacology 12 BaraczS

Cross-sectional studies also linked abnormal TC, HDL, LDL, and TG levels to DED progression, potentially through impaired tear film stability and meibomian gland dysfunction (MGD) [49]

This has implications for the genetic diagnosis of THAP1 dystonia and supports the use of broader strategies like targeted next generation or whole exome sequencing in this population