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Heme oxygenase-1 (HO-1), a cytoprotective enzyme, was upregulated upon treatment with erastin or RSL3 in renal proximal tubule cells, while deletion of HO-1 increased the cellular susceptibility to erastin-induced ferroptosis [37]

Therefore, under a light microscope, the protransfersome can be seen to possess a palisade crystalline liquid form, whereas transfersomes are vesicular when in liquid media 24