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Bayley EM, Zhou N, Mitchell KG, Antonoff MB, Mehran RJ, Rice DC, Sepesi B, Swisher SG , Vaporciyan AA, Walsh GL, Cinciripini PM, Karam-Hage M, Roth JA, Hofstetter WL

Downstream of the receptors, the phosphatidylinositol-3-kinase (PI3K)-Akt and mitogen-activated protein kinase (MAPK) are candidate signalling pathways that mediate FASN expression through the sterol regulatory element-binding protein 1c (SREBP-1c)

The results we obtained in the GSTP1-deficient MCF-7 cell line further support the active role of GSTP1 in HPV-16 E7-related survival, where HPV-16 E7 expression did not protect MCF-7 cells from UV radiation-induced damage, unless GSTP1 was forcibly co-expressed in this model system

doi: 10.1038/s41392-023-01720-0 184 LiJWangH