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Due to the generally higher metabolic activity in cancer cells and the increased levels of ROS associated with cancer progression, they may be more susceptible to ferroptosis ( 6 MM and ferroptosis 6.1 Lipid metabolism pathway 6.1.1 AA pathway Studies have demonstrated significant reductions in key PUFAs, including ferroptosis-inducing AA, within bone marrow aspirates of MM patients ( Intriguingly, MM plasma cells exhibit elevated GPX4 and xCT levels compared to normal counterparts

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Another source of deficiency can be malabsorption issues, where the body is unable to properly absorb B12 from the intestines due to various gastrointestinal disorders

Our study confirmed important alterations in the oxidative-antioxidative system in patients suffering from SM-induced lung injuries, as shown by a decreased serum level of GSH and an increased level of MDA