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7.3.4 Clinical implications and problems The potential of probiotics as a therapeutic strategy for mitigating BBB dysfunction and cognitive decline is supported by promising preclinical findings, but clinical evidence remains limited (Sproten et al., 2024)

However, biotin at very high doses (300 mg daily) has rarely caused mild diarrhea, and one case report linked biotin plus pantothenic acid to a rare inflammatory chest condition

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