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First, due to the low occurrence of liver toxicity during VPA therapy (1/600-1/800 in pediatric patients, 1/20,000 in the general population) ( In conclusion, this study demonstrated that the MTHFR A1298C and MTHFR C677T polymorphisms as well as increased serum Hcy levels contributed to the progression of VPA-induced liver dysfunction in epileptic patients via oxidative stress pathway

Briefly, cells were treated with PBS, 5-FU, and oxaliplatin, respectively, for 48 h

It enters the interstitial fluid and is then absorbed into the bloodstream, achieving high bioavailability

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