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J Subst Use

doi: 10.1111/bdi.12159 64 SeveranceEGPrandovszkyECastiglioneJYolkenRH

101 In COPD, increases in cAMP levels, activation of PKA and enhanced protein phosphorylation have the potential to reduce inflammation and immunomodulation, relax airway smooth muscle, inhibit chemotaxis and abnormal release of inflammatory and cytotoxic mediators, and reduce proliferation and migration of inflammatory cells