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The majority of QIs was reduced back to the respective parent compound (50% of AQ-QI and 80% of DEAQ-QI), presumably by the action of endogenous antioxidants and/or reductases, e.g., quinone reductases ( Figure 5B )

Journal of Microbiology and Biotechnology

Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-B/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation

Additional investigations are warranted to explore the fundamental mechanisms and validate the clinical significance of capsaicin as a specific intervention for modifying DNA methylation and expression patterns of genes associated with medical conditions (25)