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Abstract Background: Chronic obstructive pulmonary disease (COPD) is a common respiratory disorder manifested as chronic airway inflammation and persistent airflow limitation with the essential mechanism as inflammatory response and oxidative stress induced by toxic exposures such as cigarette smoke (CS)

COA verification is particularly important for GHK-Cu because the active compound requires precise copper-to-peptide ratios: too little copper reduces efficacy while excess free copper in a preparation could cause local tissue irritation or contribute to systemic copper accumulation in patients with impaired copper metabolism