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Its often asymptomatic progression leads to nearly half of cases being diagnosed at advanced stages, limiting therapeutic efficacy ( To systematize cancer complexity, the hallmarks framework was established and later expanded to encompass 14 capabilities acquired during tumorigenesis, defining core functions that drive malignant progression and guide therapeutic targeting ( Under physiological conditions, L-arginine homeostasis is tightly controlled through a coordinated network of extracellular transport, intracellular synthesis, and enzymatic conversion

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Simvastatin inhibited Mtb infection by increasing apoptosis, autophagy, cytokine release, and NKT cell generation, and could assist in enhancing the anti-TB activity of first-line anti-TB drugs and shorten the cure time (Dutta et al., 2016