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By precisely controlling gene expression involving hormone precursors, receptors, and transcriptional regulators, these ncRNAs within the HPG axis influence the production and release of important hormones, such as gonadotropin-releasing hormone (GnRH) from the hypothalamus and LH and follicle-stimulating hormone (FSH) from the pituitary

We believe clarifying this information addresses, in part, commenters' requests for CMS to provide transparency around the type of information CMS will request from ACOs as part of the reopening request process, and to address concerns over whether the information CMS may request would be readily available to ACOs

That complementarity is why the two are so often paired

It is a coordinated biochemical intervention that works through two of the most powerful metabolic hormones the body produces naturally