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Results Combinatorial CRISPR screening approach to interrogate SLC25 transporters We utilized a dual Cas9 enzyme-based knockout strategy 15 to probe all 53 human SLC25 family members in a pair-wise manner in pooled format

Studies reported that NF-B inhibition in HepG2 cells could increase the levels of ROS, MDA, and Fe 2+ , and concurrently deplete GSH, thereby intensifying lipid peroxidation and inducing ferroptosis [88] (circle marked C in Fig