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Trichloroacetic acid (TCA) is applied to the hyperpigmented areas with a cotton swab and left for a duration depending on the patients skin type

Iizuka K, Bruick RK, Liang G, Horton JD, Uyeda K (2004) Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis

Although the specific underlying mechanisms of NAFLD and NASH are unclear, patients with these diseases are insulin-resistant, revealing a clear association between liver diseases and insulin resistance (280)

Direct inactivation of the enzyme tyrosinase Switching off the production of the Eumelanin (gives darker complexion) Switching on the production of the Pheomelanin (gives brighter complexion) Sun exposure and oxidative stress can disrupt melanin levels, leading to an increase in Eumelanin for a darker complexion, and a decrease in Pheomelanin, resulting in a brighter tone