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doi: 10.1146/annurev-cancerbio-041916-065808 11 FlorosKVCaiJJacobSKurupiRFairchildCKShendeMet al

Intravenous administration of cyanocobalamin provides less chance for liver storage because of more rapid excretion than IM or subcutaneous doses

doi: 10.1126/science.aad0116

Thus, prompt assessment and treatment of severe hyponatremia is necessary to prevent the development of severe neurological complications, such as seizures and coma, and to reduce the length of hospital stay and prevent further morbidity and mortality