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Supplemental Materials Supplementary Figure 1

Several studies have demonstrated the antimutagenic properties of both fermented and unfermented rooibos extracts using various test systems

This is believed to lead to activation of the MPTP due to oxidative stress and depletion of ATP, resulting in apoptosis or necrosis, dependent on the severity of mitochondrial dysfunction and the degree of ATP loss (Visentin et al., 2020