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Resveratrol (RESV) has been extensively utilized in TRP channel regulation due to its pharmacological properties, which include antioxidant and TRP inhibitory effects

Nano Converg 9:21 Acknowledgements The authors have nothing to report

doi: 10.3390/antiox10071020 123 ZhaoCZhaoW

39,40,41,42 This process requires an active escort mechanism, whereby the AAA+ ATPase p97/valosin-containing protein (VCP) (known as Cdc48 in yeasts) extracts misfolded, damaged, or improperly synthesized proteins from the ER to enable their recognition and processing by ER-dedicated E3 ubiquitin ligases, which mark them for degradation by the 26S proteasome