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IPR003115) and then filtered based on the presence of the strictly conserved SRX-N terminal binding motif F ( S / G ) GCHR that is required for SRX catalytic activity 88

Abstract The biogenic amine, histamine, has been shown to critically modulate inflammatory processes as well as the properties of neurons and synapses in the brain, and is also implicated in the emergence of neurodevelopmental disorders

The discovery that the G2019S mutation results in a constitutive two- to threefold increase in LRRK2 kinase activity [141, 142], along with evidence that LRRK2 mutations are risk factors for the more common sporadic form of PD [143, 144], prompted extensive investigation into its functional role

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