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The Recommended Daily Allowance of B12 for adults is 2.4mcg

doi: 10.3892/or.2018.6762 313 ZhangWCaiXYuJLuXQianQQianW

These changes are reflected in shifts in curcumins log P value, which decreases (from 3.2) with increased polarity upon hydroxyl group deprotonation, enhancing its water solubility and facilitating its elimination (83)