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Peripheral Neuropathy Numbness Tingling Weakness Burning pain in the hands or feet Cognitive and Neurological Changes Memory difficulties Depression Irritability Fatigue Difficulty concentrating Sleep disturbances If left untreated for prolonged periods, some neurological complications may become irreversible

doi: 10.1016/j.molcel.2006.01.009

pmid:12395179

By integrating these mechanistic insights with emerging data on how disrupted lipid and glucose metabolism amplify immune dysregulation, the review underscores the interplay between metabolic and inflammatory pathways in exacerbating tissue injury across these organs