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The longer effective tissue exposure is consistent with the actin-sequestration mechanism, which depends on intracellular accumulation rather than transient extracellular signaling

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Clemmons DR, Moses AC, McKay MJ, Sommer A, Rosen DM, Ruckle J: The combination of insulin-like growth factor I and insulin-like growth factor-binding protein-3 reduces insulin requirements in insulin-dependent type 1 diabetes: evidence for in vivo biological activity