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TPP conjugates enhance the accumulation of chemopreventive agents in tumor cell mitochondria, enhancing efficacy and reducing toxicity to normal tissues (131)

La Rose AM, Bazioti V, Hoogerland JA, Svendsen AF, Groenen AG, Van Faassen M, Rutten MGS, Kloosterhuis NJ, Dethmers-Ausema B, Nijland JH, Mithieux G, Rajas F, Kuipers F, Lukens MV, Soehnlein O, Oosterveer MH, Westerterp M

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Potential molecular mechanisms of ALCAR activity include: (1) acetylation of -NH 2 and -OH functional groups in amino acids and N terminal amino acids in peptides and proteins resulting in modification of their structure, dynamics, function and turnover