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The pathogenic mROS production in macrophages could be successfully perturbed by BPTES and CB-839 (GLS1 inhibitors) and R162 (GLUD1 inhibitor) (69)

PDHB expression is downregulated in various cancers, including COAD, head and neck squamous cell carcinoma (HNSC), KIRC, LUSC, rectal adenocarcinoma (READ), and thyroid carcinoma (THCA)