mitochondrial glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells Mitochondrial Ca2+-overloading by oxygen/glutathione depletion-boosted

Mitochondrial Ca2+ overloading by oxygen glutathione depletion boosted photodynamic therapy based on a CaCO3 nanoplatform for tumor synergistic therapy ScienceDirect A Glutathione Activatable Ion Channel Induces Apoptosis in Cancer Cells by Depleting Intracellular Glutathione Levels Malla 2020 Angewandte Chemie International Edition Wiley Online Library Glutathione Depletion Pathways 1. Precursor Depletion Key bottleneck: Cysteine availability. Source: Diet or hepatic transsulfuration (methionine homocysteine cysteine). Failure mode: Downregulation of cystathionine lyase (CSE) during Mitochondrial Glutathione: Regulation and Functions Gaetano Calabrese, Bruce Morgan, Jan Riemer, 2017

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