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In fact, when they looked at cardiac and mitochondrial function, the researchers found no difference between the FA mice treated with the virus-delivered frataxin gene and normal, untreated mice

TMA and TMAO enterohepatic metabolite: carnitine can be converted by the intestinal microbiota to trimethylamine (TMA), and then in the liver to trimethylamine-N-oxide (TMAO) a metabolite associated with cardiovascular risk in the literature (Karlic and Lohninger 2004